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Also, pentadecapeptide BPC 157, given peripherally, could affect sphincter function through serotonin (51, 52) or dopamine (in the same dose-range that BPC 157 prevented/reversed catalepsy or stereotypy and all concomitant gastrointestinal lesions) (53-56), likely providing a particular balance between peripheral and central effects (57)

Nature Cell Biology , 24 (6), 896905

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doi:10.1016/J.COPH.2007.04.005 27

T1 works by activating toll-like receptors and modulating dendritic cell maturation, making it particularly valuable for autoimmune gut disorders

This modifier indicates that the medical necessity criteria for a DSNRB have been met