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Regarding pain modulation, various studies have reported that GLP-1 analogs exert antinociceptive effects on the central nervous system

Ann Clin Lab Sci 2015;45:287291

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Detailed mapping of proteolytic pathways revealed that peptides undergo a coordinated cascade of degradation, starting with pepsin in the stomach, followed by trypsin, chymotrypsin, and elastase in the small intestine, and culminating in peptidases located on the epithelial brush border and within enterocytes (Morishita and Peppas, 2006)