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And while gastric sleeve carries fewer surgical risks, a large analysis of nearly 100,000 patients showed that more people needed to have the surgery redone when it was a sleeve operation versus bypass

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Elevated expression of asparagine synthetase (ASNS), which transfers an amide group from glutamine to aspartate for asparagine formation, is associated with resistance to asparaginase therapy in ALL (Lomelino et al., 2017)

Integration with photothermal or photodynamic therapy has further enhanced this paradigm, creating hybrid platforms capable of stimulus-responsive, multi-mechanistic tumor eradication [422,423,424]