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The compound is not yet standard of care and remains investigational

Furthermore, ibrutinib-resistant CLL cells demonstrate increased glutamine uptake, and ibrutinib causes glutamate depletion and promotes -ketoglutarate synthesis (19)

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EMBO Mol Med 13(6):e13074 Kayvanpour E, Sedaghat-Hamedani F, Amr A, Lai A, Haas J, Holzer DB, Frese KS, Keller A, Jensen K, Katus HA, Meder B (2017) Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals

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Dominique Bridon is listed in [10] under the referenced citations