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Understanding peptide delivery methods reveals why this is such a significant challenge

However, in terms of atherosclerosis, the most important physiological function of PONs appears to be their ability to protect against LDL oxidation (428)

In cases where hypersensitivity is confirmed, desensitization protocols have been developed to allow patients to continue receiving necessary vitamin B12 supplementation safely

This has been demonstrated by Gough et al

Peptides synthesized with even single amino-acid substitutions lose receptor binding affinity and therapeutic effect