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The concept of targeting Wnt signals as a therapeutic approaches for alopecia stemmed from important role of Wnt/-catenin signaling in hair development and growth 3,4
Jacobs DR Jr., Woo JG, Sinaiko AR, et al
However, human epidemiological evidence for transgenerational effects remains limited, primarily due to the extended timeframes required for multigenerational studies and the practical challenges of maintaining long-term cohorts across decades ( Low-Dose Chronic Exposure Effects Present Assessment Challenges EEDs frequently exhibit non-monotonic dose-response (NMDR) patterns, where low-dose chronic exposure may produce more pronounced biological effects than acute high-dose exposure