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PD PD is primarily attributed to the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta, accompanied by the accumulation of Lewy bodies and Lewy neurites, predominantly comprising -synuclein, in degenerating neurons [217]

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2005, doi: 10.1196/annals.1344.013

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As a result, the release of IL-1, IL-6 and TNF- in the colon is reduced, the expression of tight junction proteins is increased, the integrity of the intestinal barrier is maintained, and the symptoms of UC mice are improved

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