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Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

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Cyanocobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)

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Methylcobalamin is more bioavailable than its synthetic counterpart, cyanocobalamin, and therefore more effective because it is absorbed more readily by the body

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