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Continuing treatment through plateaus often leads to further improvement

(2) Fiona OLeary and Samir Samman (2010) Vitamin B12 in Health and Disease Nutrients, 2010 Mar 5, Volume 2 (Issue 3), Pages 299316

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We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

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Injury and inflammation to the pigmented layer of the retina (retinal pigment epithelium or RPE) as well as the choroid cause an altered and abnormal diffusion of nutrients to the retina and RPE, possibly precipitating further RPE and retinal damage (Zarbin 2004)