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This process, called central sensitization, involves neuroinflammation, specifically activation of microglial cells in the brain and spinal cord

The company plans to submit for a type 2 diabetes indication in 2026 as well, with potential approval for that indication in 2027

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L cells express TNF receptor 1 (TNFR1) and chronic exposure to TNF was shown to impair GLP-1 (95) as well as GLP-2 secretion (96)

In addition, the compact format supports easier storage and transport within professional research settings