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The principal cytochrome P450 isoenzyme involved appears to be CYP2E1, with CYP1A2 and CYP3A4 as additional pathways

In a separate trial involving 122 cancer patients, a daily dose of 400 mcg oral selenium prevented cisplatin-induced acute kidney injury when added to hydration therapy (Ghorbani, Omidvar 2013)

Antioxidant Protection Increases endogenous antioxidant enzymes (e.g., superoxide dismutase)

May-Jun 2005;25(3b):1969-1975

New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential