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In the brain, GLP-1 agonists reduce signalling and activity in the parts of the brain that make food rewarding and tell us that were hungry

CivicScience has data on over 135K GLP-1 users, providing a unique lens into these medications societal, cultural, and economic impact

In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance

A KFF tracking poll in May found 6% of US adults were currently taking a GLP-1 medication, and 1 in 8 had taken one either for weight loss or to treat a condition like diabetes

Areas of peer-reviewed scientific inquiry where this compound has appeared

Estimates suggest that over one-third of diabetes cases result from population growth and aging, with 28% attributed to an increase in age-specific prevalence