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Combination experiments are possible but require careful controls for each component since Matrixyl 3000 contains two different peptides (Pal-GHK and Pal-GQPR) with different mechanisms

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Due to its capacity to keep moisture in your skin, the skin-healthy nutrient niacinamide (B-3) helps protect your skin's texture by constructing skin-healthy protein

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doi:10.1111/j.1530-0277.2006.00260.x

Retinoids thin the stratum corneum temporarily, which increases the risk of irritation when paired with mechanical micro-channeling