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After month 12, weight loss typically slows significantly as the body approaches a new equilibrium

The medication's primary gastrointestinal side effectsparticularly nausea, vomiting, and diarrheacan lead to dehydration if fluid intake is inadequate or losses are not appropriately replaced

doi: 10.1136/jcp.2009.072561 114 KomaroffAL

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While semaglutide demonstrated a favorable safety and tolerability profile and was associated with modest changes in AD-related biomarkers, including plasma high-sensitivity C-reactive protein and AD-relevant cerebrospinal fluid biomarkers, it did not demonstrate superiority over placebo on the primary clinical endpoint, change in the clinical dementia ratingsum of boxes (CDR-SB) score at week 104 68

Animal Chemistry