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(6) Rapid tachyphylaxis: Continued tyramine exposure depletes releasable NE stores and replaces NE with pharmacologically weak false neurotransmitter stores, leading to diminished responsiveness despite ongoing tyramine presence

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Our caseoccurring after PD-1 inhibition and in the setting of postoperative pneumonia and HPA-axis activationhad a latency of approximately 10 days, consistent with a primary drug-specific hypersensitivity response but within a complex perioperative immune environment

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