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Type-2 diabetes and cognitive function in a non-demented population

Their primary effect is to reduce hunger drive by: Enhancing satiety signaling Slowing gastric emptying Dampening reward-driven food intake via dopamine pathways

GLP-1 for weight loss Medically reviewed by Dr Crystal Wyllie Last reviewed: 19 Jun 2026 Glucagon-like peptide-1 (GLP-1) agonists are a popular weight loss treatment in the UK

Vegetables, wholegrains, beans, nuts and seeds, and pulses are the best sources of fibre

10.1002/glia.10188

This has not been tested in a dedicated maintenance RCT, but the dose-response data from STEP-2 (semaglutide 1.0 mg in T2D, Lancet 2021) showing 9.6% weight loss at 68 weeks [13] and SURMOUNT-1 showing 15.0% for tirzepatide 5 mg [7] suggest these lower doses are not inert