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Using an alternative strategy, targeting tumor endothelium and TEM8-positive malignant cells by employing TEM8-specific CAR T cells was effective in treating triple negative breast cancer (TNBC) patient derived xenograft (PDX) models and metastatic TNBC cell-line xenografts [324]
It is important to note that the majority of this mechanistic research has been conducted in cell culture and animal models, with a significant proportion originating from a single research group
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