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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

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169 Together, these findings question the relevance of such tumor models for humans and complicate the translation of interventions tested in mice to human subjects

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It was shown that keratinocytes can influence melanocyte function and survival through several mechanisms and are involved in a vitiligo potential patho-mechanism