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Beyond histamine, activated mast cells also release other inflammatory mediators like prostaglandins, heparin, and tryptase

The most significant outcome observed in this study was the improvement of the visual acuity by 21% in Pycnogenol patients compared to baseline and placebo patients, which was assessed with the Snellen chart

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The 15-residue linear sequence contains no cysteine residues, no disulfide constraints, and no unnatural amino acids, yet it maintains stability under conditions that would degrade nearly any other peptide of comparable size

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Signal sensitivity pulsed dosing is the conservative way to avoid blunting the response over time