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Basal serum concentrations of the endocannabinoid ligands N-arachidonylethanolamide and 2-arachidonoylglycerol were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity (Hill et al., 2009)

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It has been reported that patients with UC show increased levels of DNA oxide, enhanced ROS production in neutrophils, and decreased antioxidant mechanisms 14

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Clinical evidence Second Nature Second Nature has published programme-specific outcomes in peer-reviewed journals