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J Endocrinol (2014) 221(1):T3141
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Clinically, cutaneous MA occurs mainly in elderly white patients, its development is slow and usually shows roughened or papilllary surface
Aging is associated with decreased reduced glutathione in cells and increased oxidized glutathione, indicating a pro-oxidizing shift in redox balance
Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)
As a result, traditional PCT protocols with Clomid or Nolvadex are not required after using MK677 alone
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