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Eur J Heart Fail (2017) 19:6977

doi: 10.1016/j.freeradbiomed.2017.07.028 49 HeinigRFrickeRWertzSNagelschmitzJLoewenS

Of importance, JM has an eGFR of 50 mL/min/1.73 m 2 with evidence of microalbuminuria

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This means orforglipron produces the same clinical effects reduced appetite, improved glycemic control, weight loss through a fundamentally different molecular interaction