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The freed B12 then binds to intrinsic factor, a protein produced by gastric parietal cells, forming a complex that travels to the terminal ileum (the last section of the small intestine) where it is absorbed into the bloodstream

FOXO4-DRI is studied in the context of cellular senescence, p53 signaling, senolytic research, and biogerontology in preclinical models

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For the 5 mg/kg IP injection, the estimated mean AUC by 3 h (AUC 03hr ) was 20.4 mgmin/mL, which accounted for more than 95% of the estimated total AUC (AUC 0- ) of 21.0 mgmin/mL

Boschetto P, Miotto D, Bononi I, Faggian D, Plebani M, Papi A, Creminon C, De Rosa E, Fabbri LM, Mapp CE