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There is increasing evidence that sepsis is an immunosuppressive disorder that increases the population of Treg cells (Leng et al., 2013), induces extensive lymphocyte apoptosis (Hotchkiss et al., 1999), impairs the recovery of nave CD8 + T cells (Condotta et al., 2013), and suppresses the CD8 + T cell response in an MHC I-dependent manner (Guo et al., 2021)

DeCampo R and Moreno SNJ

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Cavestro C, Bedogni G, Molinari F, Mandrino S, Rota E, Frigeri MC