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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts

The NAA produced in neurons is transported to the cytosol of oligodendrocytes (as well as astrocytes) via the action of the sodium-dicarboxylate cotransporter encoded by the SLC13A3 gene