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It operates upstream of ipamorelin in the GH axis

Epithalon Mechanism of Action (Based on Research) Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) investigated for its potential to modulate aging-related biological processes

The half-life of CuHSA demetallation in the presence of EDTA was 2030 min (Fig

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References Int J Mol Sci (MDPI) Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (2025) PMC/Biogerontology Epitalon increases telomere length in human cell lines through telomerase upregulation Neuroendocrinology Letters (PubMed) Synthetic tetrapeptide Epitalon restores neuroendocrine regulation in senescent monkeys Bull Exp Biol Med (PubMed) Geroprotective effect of epithalamine in elderly with accelerated aging (12-year RCT) Alzheimers Drug Discovery Foundation Epithalamin/Epithalon Cognitive Vitality Report (mechanisms, dosing, safety) JPT Peptide Technologies Peptide Stability: How Long Do Peptides Last