A previous mediation analysis of semaglutide in adults with overweight or obesity suggested that less than one percentage point of the body weight reduction achieved with subcutaneous semaglutide was attributable to gastrointestinal adverse events (246)
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Both belong to a new generation of injectable peptide-based therapies that work by targeting multiple hormonal pathways simultaneously, offering potentially greater metabolic benefits than earlier single-receptor agents
Teichman and colleagues, for example, documented prolonged and amplified GH and IGF-1 secretion using a long-acting GHRH analog, illustrating how the GHRH side of the equation can be optimized
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