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coli , this system includes the disulfide isomerase DsbC/G and the reductive power from DsbD, which itself is coupled to the cytoplasmic NADPH pool through Thioredoxin A (TrxA) (Andersen et al., 1997

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Competing interests Nik Krajnc: has participated in meetings sponsored by, received speaker honoraria or travel funding from BMS/Celgene, Janssen-Cilag, Merck, Novartis, Roche and Sanofi-Genzyme and held a grant for a Multiple Sclerosis Clinical Training Fellowship Programme from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)