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While these medications can lead to significant weight loss, there are questions about how to combat side effects such as loss of muscle mass

Many people do better with a smaller evening meal and a larger meal earlier in the day

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Herman R.J., Hayes M.R., Audrain-McGovern J., Ashare R.L., Schmidt H.D

You have established strong lifestyle foundations If you have used your time on medication to build sustainable habits, including regular exercise, a high-protein diet , consistent sleep, and stress management, you have a much stronger foundation for discontinuation than someone who relied primarily on the medication appetite suppression without changing underlying behaviors

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Thorwald et al., 2025)