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By comparison, the DPP-4 inhibitors, saxagliptin and alogliptin, carry a regulatory warning about the finding of an increased risk of hospitalization for heart failure in treated patients enrolled in large-scale trials carried out with these drugs [57]

10 The different cell types in the islets are known to be able to influence each others activity via paracrine communication, and additionally, they can regulate their activity via autocrine feedback

approved in 2006), saxagliptin, linagliptin, and alogliptin

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