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Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-III conjugate as a potential anticancer drug

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The anti-apoptotic functions of GIP are largely mediated by the PKA-dependent phosphorylation of CREB, whilst the influence of GLP-1 on apoptosis requires PI3K [101, 104]

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Age-related changes in kidney function and body composition mean that elderly patients may experience slightly prolonged drug exposure, though specific dose adjustments based solely on age are typically not required