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Animal studies also have suggested an increased, dose-dependent risk for thyroid C-cell tumors with GLP-1 agonists

If symptoms are difficult to tolerate, a provider may recommend staying at a lower dose longer, delaying a dose increase, adjusting nutrition habits, or considering another treatment approach

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The most prescribed pre-index diabetes medications include metformin (75.1%), GLP-1 RAs (excluding OW sema T2D, 54.3%), and insulin (53.5%) ( Figure 2 )

Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: a large population-based matched cohort study

Doses of 4 mg to 8 mg work well for most people