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However, GLS inhibition was found to impair CD8 + T-cell activation in STK11-/LKB1-deficient lung cancer, and the use of CB-839 to inhibit CD8 + T-cell expansion negatively impacted tumor therapy [142]

[Consult le 13 octobre 2010] www.catie.ca 29

Clinical documentation in the medical record carries the audit trail Per-encounter notes link back to consent, clinical rationale, adverse-event context, and outcomes over time

Altogether, initial reports of NAD + precursors and exercise in clinical trials, while encouraging in certain instances, are still too inconclusive to directly link an increase in NAD + levels and mitochondrial metabolism to established health benefits in humans