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Moreover, exendin-4 inhibits NF-B activity by hindering the breakdown of IB (NF-kappa-B inhibitor alpha) in LPS-stimulated primary microglia, which reduces the activation of microglia and the generation of pro-inflammatory cytokines [113]

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The illness trajectory is highly variable, marked by frequent shifts in symptom polarity, underscoring the chronic and recurrent nature of BD (Grande et al., 2016)

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