10.1158/1078-0432.Ccr-19-2853 8 AriiS.MiseM.HaradaT.FurutaniM.IshigamiS.NiwanoM.et al (1996)
This Study is only meant to provide early-stage indicative information to Lexaria about the possibility of enhancing the pharmacokinetic (PK) and pharmacodynamic performance of orally delivered GLP-1 drugs to assist in guiding the Lexaria team in additional investigations
Since the primary, if not exclusive, source of GLP-1 in the CSF are brainstem GLP-1 neurons (and not GLP-1 from the circulation 3 ), this suggests that CSF-contacting neurons are regulated by the overall activity of brainstem GLP-1 neurons
GLP-1 therapy is ideal for adults with a BMI of 27 or higher, those struggling with appetite control or metabolic issues, and individuals with prediabetes or type 2 diabetes
[4] Huber, H., Schieren, A., Holst, J
The nausea was brutal for the first two months, and even at the highest dose, I just stopped losing around month five