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Description

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doi: 10.1111/j.1476-5381.2011.01272.x 50 JolivaltCGFinemanMDeaconCFCarrRDCalcuttNA

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In vacuoles of macrophages where phagocytosed bacteria are killed, itaconate inhibits the bacterial enzyme, isocitrate lyase (ICL), a bacterial enzyme required for the glyoxylate shunt that functions during host infection by bacteria

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