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Because dilution occurs with intravascular serum and blood, osmotic solutions have their greatest effect at or near the site of injection

Recognition of this has spurred a number of innovative approaches that, despite their preclinical promise, have yielded disappointing efforts at translation into a meaningful clinical role

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Cheng, J., Wang, C., Feng, D., Zheng, R., Xu, Y., Zhang, C

Ueta M, Sawai H, Shingaki R, Kawai Y, Sotozono C, Kojima K, Yoon KC, Kim MK, Seo KY, Joo CK, Nagasaki M, Kinoshita S, Tokunaga K (2017) Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications

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