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Cartilage and joint repair models: Intraarticular injection of AOD9604 in a collagenase induced rabbit osteoarthritis model showed improved cartilage architecture and regeneration

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The animal literature largely used systemic routes (intraperitoneal), and the results were consistent regardless of injection location

Most payers adjudicating the resulting claims cannot because PREVENT requires measured lab values and vitals that simply don't exist in claims data