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Acknowledgements The authors are thankful to the Plant Physiology and Molecular Systematics and Applied Ethnobotany Lab

Lactate Dehydrogenase (LDH) Assay In this assay performed on HaCaT keratinocytes cells, the cells were treated with GHK, GHK-Cu, CuCl 2 and Cu(OAc) 2 for 30 mins at 7 different concentrations each, ranging from 0.0058 to 5800 M0.0058 M, 0.058 M, 0.58 M, 5.8 M, 58 M, 580 M, 5800 M

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GHK-Cu (glycyl-L-histidyl-L-lysine copper peptide) is a naturally occurring tripeptide found in human plasma, saliva, and urine