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To prevent acidification of the cell, pyruvate is also transaminated into alanine and lactate is transported out of the cell thereby acidifying the extracellular environment

doi: 10.3748/wjg.v12.i26.4117 61 MunroeDGGuptaAKKoosheshFVyasTBRizkallaGWangHet al

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Tregs, typically referred to as CD4 + CD25+Foxp3+ T cells, can survive in tumor microenvironments with persistent oxidative stress