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They evolved from years of trials, clinical use, and ongoing data collection

Wegovy is intended for patients who are overweight, obese, or have weight-related health issues

first of all, the presence of proteolytic processes both in the gastrointestinal tract and inside the cells might reduce the recombinant protein levels, making their detection technically difficult and reducing the therapeutic impact

Thus, timing matters avoid initiating during active wound repair phase

10.1038/cdd.2014.139 Cell Death Differ