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By comparison, the DPP-4 inhibitors, saxagliptin and alogliptin, carry a regulatory warning about the finding of an increased risk of hospitalization for heart failure in treated patients enrolled in large-scale trials carried out with these drugs [57]

A plethora of other gut released peptides exist to be explored: Amylin [46] , peptide YY (PYY) [47] , Cholecystokinin (CCK), secretin, neurotensin, somatostatin (SST) and ghrelin to name a few