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89 The potential clinical relevance is further clarified in rats fed a high-fat diet for 4 weeks that treatment with a GLP-1R agonist liraglutide not only restores insulin-mediated skeletal muscle microvascular perfusion but also prevents high-fat diet-induced reduction in muscle capillary density

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The risk of systemic complications was lower across several parameters (HR 0.320.71)

47 Because of the high prevalence of frailty and sarcopenic obesity in the HFpEF population, future studies are required to estimate the proportion of lean body mass loss versus fat loss on GLP-1 RA therapy to identify predictors of the disproportionate loss of muscle mass

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Acc Chem Res Am Chem Soc (ACS)