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In parallel, triple agonists simultaneously targeting GIP, GLP-1, and GCG receptors are also under investigation, aiming to deliver greater WL and metabolic improvements than mono- or dual-agonists

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Theoretically, nanoparticles (NPs) encapsulating GLP-1RAs can significantly extend the drugs half-life and promote accumulation of the drug in the joint cartilage, thereby maintaining a high therapeutic concentration for an extended period and improving treatment efficacy

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