Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C et al
Role of Ascorbate in the Generation of Endogenous Oxalate Oxalate is present in many foods such as spinach, chard, nuts, black pepper, poppy seeds, and also occurs as a result of the metabolism of ascorbic acid, and the amino acids glycine, serine, and 4-hydroxyproline as well as metabolism of ethanolamine
However, it can cause steatorrhea, resulting in fat-soluble vitamin deficiency, and can even cause liver damage
Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden
There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier
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