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Eryptosis, analogous to apoptosis in nucleated cells, is a physiological process that eliminates senescent or defective erythrocytes before hemolysis occurs, thereby preventing toxicity resulting from the release of hemoglobin into the bloodstream

JANUVIA WORKs in 2 ways with a glucose-dependent mechanism of actION increasing insulin production and reducing hepatic glucose production DPP-4 Inhibition Oral glucose stimulates release of incretins (GLP-1 and GIP) DPP-4 rapidly degrades incretins JANUVIA inhibits DPP-4 to increase active incretins

Building tolerance over the first week matters more here than accelerating results

As with any medication, microdosing GLP-1 drugs should be undertaken under the guidance of a healthcare provider

PLoS Pathog 2 , e59 (2006)

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