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When we try to look at the effects on glucose and insulin and doing what we call dose response experiments, where we increase the dose to see how much you can actually obtain with this, then we also found, as we increased the doses, people would start to get sick

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PEX-168 is a new agent of long-acting GLP-1R agonist, which is molecularly modified from EX via amino acid modification and PEGylation (119), the first GLP-1R agonist modified by PEG to achieve long-term pharmacological action (120, 121)