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The practical implication is that GHK-Cu addresses structural skin aging (collagen loss, elasticity decline) while neurotransmitter-modulating peptides address dynamic wrinkles (expression lines)

The sirtuins are NAD + -dependent deacetylases that are distributed in the nucleus (e.g., SIRT1, SIRT6, and SIRT7), the cytoplasm (e.g., SIRT2) and mitochondria (e.g., SIRT3-5), respectively

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Sharp discontinuity of either Dpp signalling or Dpp targets can induce JNK-dependent apoptosis which results in aberrant morphogenesis 17, 18, 26

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