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Differential expression analysis was performed using DESeq2 (v1.28.1), and pathway enrichment analysis was conducted using GSEA (v4.2.3) with MSigDB (v7.4)

This allows your healthcare provider to assess wound healing, blood pressure stability, thyroid function, and mental health before GLP-1 therapy begins

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Pioneer Trial Oral formulation of GLP-1 RA was recently developed and based on the Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) programme (PIONEER) program, phase III clinical trials showing the efficacy and safety of oral semaglutide in comparison with placebo or other medications

Realistic Expectations Healthy weight loss: 0.51 kg per week Rapid weight loss is not always sustainable Plateaus are normal after initial progress These medications are designed for long-term management , not quick fixes

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