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Meta-analyses indicate that GLP-1RAs generally reduce HOMA-IR and improve fasting blood glucose and 2 h OGTT levels in the PCOS population (78)

e Intact mass spectrometry analysis confirming conversion of the sulfonyl fluoride version of the YPEL5-interacting fragment of ZZ2 to its acidic sulfinic acid derivative (upon overnight incubation in a DTT-containing buffer)

The neurochemical basis of these symptoms is multifactorial

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